Potassium Channel

KcsA

Potassium Channel

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (751)
Antibodies (5)

By Effects:	Controls (5) Inhibitors (483) Agonists (10) Antagonists (30) Activators (147) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P1424

Lei-Dab7	Inhibitor
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a K_d of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels.

HY-126486

AVE1231	Inhibitor	98.61%
AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC₅₀=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation.

HY-121520

Docosahexaenoyl glycine	Activator
Docosahexaenoyl glycine is a PUFA analogue. Docosahexaenoyl glycine has activating effects on IKs?channels?and restore the function of IKs?channels with LQT1 mutation.

HY-P10255

K90-114TAT	Inhibitor
K90-114TAT is an inhibitor for EAG2-Kvβ2 interaction, and exhibits antitumor efficacy against glioblastomas.

HY-153746

Kv3 modulator 5	Modulator
Kv3 modulator 5 (Example 5) is a Kv3 channel modulator. Kv3 modulator 5 increases the Kv3.2 current. Kv3 modulator 5 can be used for research of hearing disorders.

HY-116478

L-3373	Inhibitor
L-3373 is a voltage-dependent potassium channel inhibitor with activity that reduces the effective refractory period and the dispersion of monophasic action potential duration, while significantly reducing susceptibility to ventricular fibrillation in a cat model of left ventricular hypertrophy.

HY-164911

VU0546110	Inhibitor
VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC₅₀s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K⁺ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential.

HY-P1426A

AmmTX3 TFA	Inhibitor
AmmTX3 TFA is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 TFA is specific blocker of K_v4 channel. AmmTX3 TFA inhibits the A-type K⁺ current (K_i: 131 nM).

HY-116556

Rilmakalim	Activator
Rilmakalim (HOE 234) is a potassium channel opener (PCO) that activates ATP-sensitive K⁺ channels in the heart or other tissues.

HY-B0254S

Glipizide-d₁₁	Inhibitor
Glipizide-d₁₁ is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].

HY-14186

KVI-020	Inhibitor
KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC₅₀ of 480 nM. KVI-020 can inhibits hERG, with an IC₅₀ of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research.

HY-B0401S1

Tolbutamide-¹³C	Inhibitor
Tolbutamide-¹³C is the ¹³C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.

HY-121183

Aprikalim	Activator
Aprikalim (RP 52891), a potassium channel opener (KCO), activates ATP-sensitive K+ (KATP) channels in guinea pig ventricular myocytes. Using patch-clamp techniques, it was found that aprikalim enhances KATP channel activity more effectively in Mg-NDP solution compared to standard solutions. In Mg-NDP solution, aprikalim reduced the sensitivity of KATP channels to ATP, increasing the concentration of ATP required to inhibit channel activity by half (K1) from 56 μM to 180 μM. However, this effect diminished over time. Aprikalim's ability to activate KATP channels in Mg-NDP solution suggests potential therapeutic implications in modulating cardiac excitability and may relate to changes in channel protein enzymatic activity under experimental conditions.

HY-118387

AVE-0118	Inhibitor
AVE-0118 is a nonselective Kv1.5 blocker with an IC₅₀ of 1.1 μM. AVE-0118 is a multichannel inhibitor with weak, micromolar activity against Kv1.5 and other ion channels. It is inactive against I_Ks, I_KATP, and L-type Ca+ channels.

HY-W415121R

Bupivacaine (hydrochloride monohydrate) (Standard)	Inhibitor
Bupivacaine (hydrochloride monohydrate) (Standard) is the analytical standard of Bupivacaine (hydrochloride monohydrate). This product is intended for research and analytical applications. Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain.

HY-B1751D

Quinidine sulfate dihydrate	Inhibitor
Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K⁺ channel blocker with an IC₅₀ of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research.

HY-P1282

Agitoxin-2	Inhibitor
Agitoxin-2 is a K+ channel inhibitor, with IC₅₀ values of 201 pM and 144 pM for mK_V1.3 and mK_V1.1, respectively).

HY-126123

NR2B-selective NMDA receptor antagonist 1	Inhibitor
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC₅₀s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier.

HY-101433

N-Acetylprocainamide hydrochloride	Inhibitor	99.83%
N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K⁺ channels.

HY-172141

Ebio2	Activator
Ebio2 is a potent KCNQ2 activator.

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (751)

Antibodies (5)

Potassium Channel Related Products (751):